ea0073aep45 | Adrenal and Cardiovascular Endocrinology | ECE2021
Zhang Wei
, Nowotny Hanna F.
, Zopp Stephanie
, Bidlingmaier Martin
, Reincke Martin
, Uhlenhaut Henriette
, Reisch Nicole
ContextE47 is a transcription factor mostly known for its role in B and T cell lineage commitment. Recently E47 was identified as a modulator of glucocorticoid receptor target genes, its loss protecting mice from metabolic adverse effects of glucocorticoids. Patients with Cushings syndrome (CS) suffer from an endogenous glucocorticoid excess due to tumour formation associated with a variety of metabolic comorbidities seriously affecting patients...